Noise is probably the thing that bothers me most while reading. I need silence. If something or someone is making a racket - whether it be music, talking, the television - I just don't take in as much of what I'm reading as I would in absolute silence. That being said, I do often read ghost stories while the TV is on in the background... but only because I'm a little scaredy-cat..
I prefer reading indoors, in bed, and I don't mind eating or drinking while I read - which is why there are pink milkshake stains in my copy of Anne Frank's diary... I should be ashamed, since the first thing they taught us way back in primary school while on a trip to the library, is to never eat or drink while handling books.