Well if the Golden Globes are anything to go by, The Social Network should pickup quite a few of these.
Edit: My pridictions as follows:
Best Actor - Colin Firth in “The King's Speech”
Best Supporting Actor - Christian Bale in “The Fighter”
Best Actress - Natalie Portman in “Black Swan”
Best Supporting Actress - Helena Bonham Carter in “The King's Speech”
Animated Feature Film - Toy Story 3
Art Direction - “Inception” - Production Design: Guy Hendrix Dyas; Set Decoration: Larry Dias and Doug Mowat
Cinematography - “Inception” Wally Pfister (I'd like to have said "The book of Eli" purely for the Gun fight in the house scene... it blew my mind!)
Costume Design - “Alice in Wonderland” Colleen Atwood
Directing - “The Social Network” David Fincher
Film Editing - “127 Hours” Jon Harris
Music (original score) - “The Social Network” Trent Reznor and Atticus Ross (It's ridiculous that Daft Punk are not nominated here for Tron. That soundtrack is astonishing)
Best Picture - Either “The King's Speech” or “The Social Network”
Short Film (animated) - “The Gruffalo” Jakob Schuh and Max Lang
Sound Editing - “Inception” Richard King
Sound Mixing - “Inception” Lora Hirschberg, Gary A. Rizzo and Ed Novick
Visual Effects - “Inception” Paul Franklin, Chris Corbould, Andrew Lockley and Peter Bebb
Writing (original screenplay) - “The King's Speech” Screenplay by David Seidler