Yes it's one of those unforgettable stories - the dangers of ennui (be happy with what you have!). I loved it and found it quite a daring book of its time - certainly didn't pull any punches and there are some brilliant scenes in it. Similar novels I've read are The Awakening by Kate Chopin and Therese Raquin by Emile Zola (I think this is my favourite Zola - he doesn't pull any punches either).
Notice that Villette is on the list - I've started and abandoned this but am determined to go back to it when I can give it the attention it deserves - it's supposed to be one of the best of the Bronte novels.