The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, and wound healing disorders. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this series excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The fifth volume brings together reviews on the following topics: - Targeted therapy for tumor vasculature - Anti-angiogenic therapy for breast and prostate cancers (including information updates on clinical trials) - Microbe-based and other novel antiangiogenesis therapies such as chromene-based agents

Advances in biomedical research have had a profound effect on human health outcomes over the last century. Biophysical, biochemical and cellular techniques are now the backbone of modern biomedical research. Understanding these laboratory techniques is a prerequisite for investigating the processes responsible for human diseases and discovering new treatment methods. Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications Provides information about basic and advanced analytical techniques applied in specific areas of life science and biomedical Key Features: - Book chapters present a broad overview of sophisticated analytical techniques used in biophysics, biochemistry and cell biology. - Techniques covered include in vitro cell culture techniques, flow cytometry, real time PCR, X-ray crystallography, RNA sequencing - Information about industrial and biomedical applications of techniques, (drug screening, disease models, functional assays, disease diagnosis, gene expression analysis and protein structure determination) is included. The book is an excellent introduction for students (as a textbook) and researchers (as a reference work). The information it presents will prepare readers to understand and develop research methods in life science laboratories for different projects and activities.

For centuries, legumes have been used as pulses or grains serving as the most critical sources of major protein/oil-producing crops for both human and animal consumption, and for providing raw materials for industrial processing. They are highly valued as soil-building crops, improving soil quality through their beneficial involvement in biological nitrogen fixation, a symbiotic partnership with rhizobia. Advances in Legume Research: Physiological Responses and Genetic Improvement for Stress Resistance serves as a unique source of information on the distinct aspects of basic and applied legume research for general readers, students, academics, and researchers. The book gives several insights on the morphological, physiological, and genetic responses to stresses via 8 concise chapters covering all aspects of legume growth, utilization, and improvement. The included chapters present research findings and succinct reviews concerning the strides continuously made in the improvement of legumes against biotic and abiotic stress factors. This comprehensive new legume reference book disseminates key information pertaining to genetic diversity, conservation, cultivation, manipulation through mutagenic techniques, plant transformation, and other breeding technologies. The book, therefore, continues to build on the need to acquire new knowledge about legume crops and ways to improve their existing agricultural yield for a sustainable and secure food market.

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The seventh volume of the series features six reviews focusing on NMR spectroscopic techniques for studying structures of protein complexes, metabolic profiling of gut bacteria, lipid digestion, lung disorders, and early cancer diagnosis, respectively.

Compendium on Cardiomyopathies provides an easily readable source of material for practicing physicians, clinicians, cardiologists, intensivists and emergency medicine specialists. It presents an overview of different cardiomyopathies with information known from the past to the present. Chapters cover different kinds of cardiomyopathies: hypertrophic cardiomyopathies, pediatric cardiomyopathies, arrhythmogenic right ventricular cardiomyopathy, inherited cardiomyopathies, Chagas disease, Takotsubo cardiomyopathy and more. Readers will be informed about current research on different aspects of these cardiomyopathies such as etiology, important imaging methods used in diagnosis and treatment, genetics and clinical management. This compendium also introduces the reader to new terms describing groups of cardiomyopathies to enable them to apply modern clinical management principles while treating patients.

Introduction: Mathematicians and statisticians have made significant academic progress on the subject of distribution theory in the last two decades, and this area of study is becoming one of the main statistical tools for the analysis of lifetime (survival) data. In many ways, lifetime distributions are the common language of survival dialogue because the framework subsumes many statistical properties of interest, such as reliability, entropy and maximum likelihood. Recent Advances in Lifetime and Reliability Models provides a comprehensive account of models and methods for lifetime models. Building from primary definitions such as density and hazard rate functions, this book presents readers a broad framework on distribution theory in survival analysis. This framework covers classical methods - such as the exponentiated distribution method – as well as recent models explaining lifetime distributions, such as the beta family and compounding models. Additionally, a detailed discussion of mathematical and statistical properties of each family, such as mixture representations, asymptotes, types of moments, order statistics, quantile functions, generating functions and estimation is presented in the book. Key Features: - presents information about classical and modern lifetime methods - covers key properties of different models in detail - explores regression models for the beta generalized family of distributions - focuses information on both theoretical fundamentals and practical aspects of implementing different models - features examples relevant to business engineering and biomedical sciences Recent Advances in Lifetime and Reliability Models will equip students, researchers and working professionals with the information to make extensive use of observational data in a variety of fields to create inferential models that make sense of lifetime data.

Stem cell and regenerative medicine research is an important area of clinical research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer’s disease and retinal disorders, among others, may well be addressed employing stem cell therapies and tissue regeneration techniques. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. This volume includes current literature on a variety of topics: -the utility of exogenous and endogenous neural stem cells in spinal cord injury -somatic cells for human induced pluripotent stem cells (iPSCs) -reactive oxygen species (ROS) mediated cellular signaling for stem cell differentiation -the therapeutic potential of microRNAs in cardiac diseases -stem cell therapy for the treatment of malaria

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The fifth volume of the series covers the following topics: -The Lipid Hypothesis: From Resins to Proprotein Convertase Subtilisin/Kexin Type-9 Inhibitors -The Role of SGLT2i in the Prevention and Treatment of Heart Failure -Natural Products and Semi-Synthetic Compounds as Antithrombotics: A Review of the Last Ten Years (2009-2019) -Transient Receptor Potential Channels: Therapeutic Targets for Cardiometabolic Diseases? -Treatment of Raynaud’s Phenomenon -Traditional Medicine Based Cardiovascular Therapeutics -Cardiovascular Disease: A Systems Biology Approach

This book is all about cloud computation. The knowledge in this book is comprehensible to everyone. The book is divided in to five chapters and each chapter contains a specific knowledge on cloud computation Chapter 1: Introduction to Cloud Computation Chapter 2: Microsoft Azure Chapter 3: Amazon Web Services Chapter 4: Amazon Programming Chapter 5: Google Cloud Platform. After reading this book the reader will be able to explain the cloud computation, difference between the cloud computation, Google, Microsoft and Amazon cloud platform. At the end of this book some abbreviations and general definitions are given

Digital Transformation in Education and Artificial Intelligence: Emerging Markets and Opportunities aims to shed light on the various advantages and drawbacks of the same along with the opportunities and markets that are emerging because of digital transformation. This volume encompasses diverse perspectives on the digital landscape for Small and Medium Enterprises (SMEs). It delves into the use of digital tools like Big Data, IoT, AI, and ML in Chapter 1, followed by an exploration of factors influencing online shopping adoption in SMEs in Ghana (Chapter 2). Chapter 3 sheds light on the digital transformation of African SMEs, while Chapter 4 offers insights into the consequences of digitalization for SMEs in Sub-Saharan Africa. The subsequent chapters cover topics such as the impact of Big Data on SMEs' performance, digitization initiatives for African telecom service providers, the role of social media as a promotional tool for SMEs in Ghana, and the utilization of Artificial Intelligence by SMEs in Africa, addressing both benefits and challenges. The chapters provide information for educators at all levels to obtain a complete understanding of the technology-based environment that impacts teaching and commerce. It also serves as a resource for policymakers, entrepreneurs, researchers, and students interested in digital transformation in Africa.