I can think of a few but they're mainly crime, however the main characters do have a disability:
C J Sansom's Shardlake series - the main character is a lawyer who has a hunchback (not a very PC term I'm afraid)
Robert Galbraith's series featuring private detective Cormoran Strike, who lost a leg in one of the recent Middle East conflicts (haven't read these for a while but I think it was in Afghanistan) - he's a troubled character but essentially decent
and then there's Game of Thrones, where one of the main characters is a person of restricted height (again sorry if that's not the correct term) but he is one of the best characters and although he is much maligned (and at one point does do something pretty awful, although he has his reasons) he is highly intelligent, witty and extremely resourceful.